Endocrine Abstracts

Introduction: In 2017 the Roche cortisol assay underwent a generation update. The increased specificity of this assay was expected to lower cortisol results by approximately 30%. Based on a local consensus, the 30 min short Synacthen Test (SST) cortisol was lowered from 550 to 420 nmol/l. With the previous assay, a morning cortisol of ≥375 nmol/L gave a 99% PPV of an SST ‘pass’.Aims: • To compare the numbers of SSTs and the SST pass ...

The number of childhood cancer survivors is ever increasing and as this population continues to grow, the long term physical and psychological impact of having cancer treatment in childhood becomes ever more apparent. Childhood cancer survivors are moving into adulthood with significant health needs secondary to their cancer treatment. Acknowledging and addressing these needs is crucial in supporting them on their continued health journey. Patients attending the ‘late eff...

Hypoparathyroidism (HP) is a rare disease characterized by an absence or inappropriately low concentrations of circulating parathyroid hormone, leading to hypocalcaemia, hypophosphatemia and elevated urinary calcium excretion.Aim: To determine complications in chronic post-surgical HP patients.Material and methods: We have analyzed the data from 76 patients (71 women and 5 men; median age 51.8 years (range 18–77)) with chronic...

Introduction: Manifestations of primary hyperparathyroidism (PHPT) such as osteoporosis and stone diseases are common primary diagnostic findings beyond a hypercalcemia. Classical skeletal involvement can be the first sign of PHPT, but not recognized because osteitis fibrosa cystica (bone cysts, brown tumors of the long bones) is rarely seen today in Western Europe.Case report: A 34-year old women from Afghanistan was presented to our out-patient-clinic ...

Background: There are about 50% of people living with undiagnosed diabetes worldwide. Moreover, by the time of diabetes diagnosis, chronic disabling complications are already present.Aim: To assess level of A1c by the time of type 2 diabetes diagnosis.Material and methods: We analyzed results of type 2 diabetes screening in three regions of the Republic of Uzbekistan among 2521 people aged 35 or older without known carbohydrates me...

Background: The incidence of hypophysitis has increased since the introduction of Immuno-oncologic treatment. Treatment with anti-CTLA-4 (Ipilimumab) and anti-PD-1 has improved the prognosis for patients with malign melanoma drastically, but immune-mediated side effects can occur in any organ, including the thyroid and the pituitary. Headache is considered a key symptom of hypophysitis. Here, we report three cases with silent, isolated ACTH-insufficiency following immunotherap...

The aim: To evaluate effectiveness of complex therapy in patients with comorbidity of type 2 diabetes (DM2) and essential hypertension (EH) depending on genetic polymorphism peroxisome proliferator-activating receptor-γ2 (PPARγ2). Before and after 3 months of treatment we examined 145 patients with EH stage II, grade and DM2 moderate, subcompensated aged 45–60 years: group 1 (71 patients) received standart therapy (telmisartan, indapamide, metformin, gliclazide,...

It is paramount to educate our patients, thereby empowering them to manage their chronic conditions. This is an evidence based fact. As healthcare professionals our challenge is to provide and ensure patients have been well informed in order to understand and manage their condition successfully on a daily basis.In today’s healthcare service patient education has become a casualty of the reduced resources; there are ever increasing restrictions on bo...

Primary aldosteronism (PHA) is one of the most common cause of secondary hypertension. It can possibly concern over 10% of hypertensive patients, but often is being under-recognised. The basic tool of case PHA detection is aldosterone to renin ratio (ARR). Appropriate cutoff value of ARR is still under discussion.We review occurrence of CT/MRI detectable adrenal gland laesions according to assigned ARR cutoff value. Retrospective data from 833 consecutiv...

Introduction: Obesity-related glomerulopathy(ORG) is a secondary form of focal segmental glomerulosclerosis (FSGS) occurring in obese patients with a body mass index(BMI) higher than 30 kg/m2.ORG is typically manifested by nephrotic-range proteinuria without full nephrotic syndrome, and progressive renal insufficiency.Case presentation: Thirty-six years old male patient (BMI 59.2 kg/m2) visited endocrinologist with complains of weig...